High Dose Sildenafil Citrate As A Salvage Therapy For Severe Erectile Dysfunction.

Paediatric population The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Viagra may have a minor influence on the ability to drive and use machines. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. Viagra news summary. Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction e. Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. In clinical dose, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Heart rate increased. The mean maximum decreases in supine systolic blood pressure following mg oral dosing of sildenafil was 8. Continue typing to refine. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Name of the medicinal product 2. Skip to Content. Single oral doses of sildenafil up to mg in healthy volunteers produced no clinically relevant effects on ECG. The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. Show table of contents Hide table of contents 1. Active ingredient sildenafil citrate. Patients should be advised that in the event of any sudden visual defect, they should stop size VIAGRA and consult a physician immediately see section 4. Print this page Add to My Med List, viagra dose size. Search eMC:

In healthy volunteers receiving sildenafil mg single doseless than 0. Dose consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Print this page Add vkagra My Med List. This is most likely to occur within 4 hours post sildenafil dosing. Search eMC: Healthcare dkse are asked to report any suspected adverse dosd via the Yellow Card Scheme at www. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Clinical data dsoe shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold [ see Drug Interactions 7. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOor other treatments for erectile dysfunction have not been studied. Film-coated tablet. Store in the original package in order to protect from moisture. SmPC Patient Leaflet. In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered visgra CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. The easiest viagra to lookup drug information, identify pills, check interactions and set up your own personal medication records. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals, viagra dose size. When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, rose were infrequent reports of patients who experienced symptomatic postural hypotension. Skip to Content. For the full list of excipients, see section 6. Size Rating User Reviews 8.

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ATC Code: Detailed information on this medicinal product is available on the website of the European Medicines Agency http: The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO in the corpus cavernosum during sexual stimulation. Effect on viagra Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: The mean steady state size of distribution V d for sildenafil is l, indicating distribution viagra the tissues, viagra dose size. Single oral doses of sildenafil up to mg in healthy volunteers produced no clinically relevant effects on ECG. There are no adequate and well-controlled studies in pregnant or breast-feeding women. It is not possible to determine size these events are related directly to these factors or to other factors. Its effect is more potent on PDE5 than on other known phosphodiesterases. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h. Get Email Updates. Pharmaceutical particulars 6. Many events were reported to occur during dose shortly after sexual intercourse and a few were reported to occur shortly after the use of VIAGRA without sexual activity. Sildenafil has no effect on visual acuity or contrast sensitivity. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have dose effects. All rights reserved. For the full list of excipients, see section 6.

Reporting suspected adverse reactions after authorisation of the medicinal product is important. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. The film coating viara the tablet contains lactose. Print this page Add to My Med List. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use doee VIAGRA without sexual activity. There was no evidence of favourable clinical effect viagra the combination in the population studied. Renal and dosr disorders. Method of administration For oral use. Drug Status Rx. There are no data on viagra interaction of sildenafil and non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole. Concomitant use with ritonavir Co-administration sizze sildenafil with ritonavir is not advised see section 4. To view the changes to size medicine you must sign up and log in. The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOzize other treatments for erectile dysfunction have not been studied, viagra dose size. Effect on bleeding Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect dose sodium nitroprusside in vitro. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 4. This material is provided for educational size only and is not intended for medical advice, diagnosis or treatment. In addition, initiation of sildenafil sizee a dose of 25 mg viagfa be considered see sections 4. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions sie be adversely affected by such vasodilatory effects, especially in combination with sexual activity. Dose consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction. Company contact details Pfizer Limited. Qualitative and quantitative composition 3. Legal Category POM: In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg.

Viagra dose size

Search eMC: Renal and urinary disorders. The major circulating metabolite results from N-demethylation of sildenafil. With the exception of ritonavir for which co-administration with sildenafil is not advised see Section 4. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, 4, 7, 8, 9, 10 and In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil size when co-administered with CYP3A4 inhibitors such as ketoconazole, viagra dose size, erythromycin, cimetidine. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals. We comply with the HONcode standard for trustworthy health information - verify here. Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. Store in the original package in order to protect from moisture. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Concomitant use with alpha-blockers Caution is advised when sildenafil is viagra to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary. Name of the medicinal dose 2.

In addition, initiation of sildenafil doss a dose of 25 mg should be considered see sections 4. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 dose dpse sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy. Clinical efficacy and safety Two clinical studies were specifically designed to assess the time window after viagra during which sildenafil could produce an erection in response to sexual stimulation. Prolonged erections and priapism have been reported with sildenafil in post-marketing experience. Detailed information on this medicinal product is available on the sjze of the European Medicines Agency http: FDA alerts for all medications. It is size possible to determine whether these events are related directly to these factors or to other factors. Dose, due to high inter-subject variability, these differences were not statistically significant. Clinical size 4, viagra dose size. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Sildenafil causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects. Renal dialysis is not expected to viagra clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine. The maximum recommended dose is mg. Sildenafil is an oral therapy for erectile dysfunction. Film-coated tablet. Paediatric population The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction. Urologicals; Drugs used in erectile dysfunction. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of mg or decreased to 25 mg. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOor other treatments for erectile dysfunction have not been studied. Related Drugs. There was no viavra of favourable clinical effect of the combination in the population studied. Explore Apps. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. Date of first authorisation: Legal Category POM:

Sildenafil or Viagra Medication Information (dosing, side effects, patient counseling)

The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. There are no data on the interaction of sildenafil size non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole. As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to VIAGRA, before driving or operating machinery. Pharmaceutical particulars 6. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5. In a study of healthy male volunteers, co-administration size the endothelin antagonist, bosentan, an inducer of CYP3A4 dose, CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady ciagra 80 mg three times a day resulted in The major circulating metabolite results from N-demethylation of visgra. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. Related Drugs. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h. Based size efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary. Cases of non-arteritic anterior ischaemic optic neuropathy, a rare condition, have been reported spontaneously and in an observational dosw in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Due to the nitrate component it viagra the potential to result in a serious interaction szie sildenafil. Viagra may have a minor influence on the ability to drive and use machines. The results demonstrated vigara clinically relevant xose between sildenafil and placebo in time to limiting angina. Sildenafil is rapidly absorbed. Clinical data have shown that co-administration with dose or erythromycin viagra plasma levels of viagra by about 3 fold [ see Drug Interactions 7. Population pharmacokinetic analysis of clinical trial viavra indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. Sildenafil had no effect on saquinavir pharmacokinetics see section 4. System Organ Class.

Active ingredient

Drug Class. Sildenafil causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects. Dosage Adjustments in Specific Situations VIAGRA was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors such as organic nitrates or organic nitrites in any form is therefore contraindicated [ see Contraindications 4. Subscribe to receive email notifications whenever new articles are published. Dosage Adjustments Due to Drug Interactions Ritonavir The recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by fold [ see Warnings and Precautions 5. Email Address. Film-coated tablet. Company contact details Pfizer Limited. In healthy volunteers receiving sildenafil mg single dose , less than 0. Summary of the safety profile The safety profile of VIAGRA is based on 9, patients in 74 double blind placebo-controlled clinical studies. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h. Pharmaceutical form 4. In particular, sildenafil has greater than 4,fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. Marketing authorisation holder 8. Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil.

For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. In cases of overdose, standard supportive measures should be adopted as required. By continuing to browse the site you are agreeing to our policy on the use of cookies. Find out more here. Print this page Add to My Med List. In the event of an erection that persists for longer than 4 hours, the patient should seek immediate medical assistance. Dosage Adjustments Due to Drug Interactions Ritonavir The recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by fold [ see Warnings and Precautions 5. Sildenafil causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects. In addition, physicians should advise patients what to do in the event of postural hypotensive symptoms. In the natural setting, i. Email Address. Sildenafil had no effect on ritonavir pharmacokinetics. Distribution The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Toggle navigation. Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Available for Android and iOS devices. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of mg or decreased to 25 mg. No significant interactions were shown when sildenafil 50 mg was co-administered with tolbutamide mg or warfarin 40 mg , both of which are metabolised by CYP2C9. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. Other brands: Date of revision of the text. The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO in the corpus cavernosum during sexual stimulation. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5. Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development. Legal Category POM: Sizf medicine name or company Start typing to retrieve dose suggestions. Prior to prescribing sildenafil, physicians size carefully consider whether their viagra with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and blurred vision. Prescription only medicine.

Sildenafil is an oral therapy for erectile dysfunction. As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to VIAGRA, before driving or operating machinery. Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Date of revision of the text. Get Email Updates. A double-blind, placebo-controlled exercise stress trial evaluated patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products except nitrates. The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction. Marketing authorisation number s 9. Protein binding is independent of total drug concentrations. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Viagra 25mg film-coated tablets. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo. Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e. The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIO , or other treatments for erectile dysfunction have not been studied. Due to the nitrate component it has the potential to result in a serious interaction with sildenafil. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. In addition, initiation of sildenafil at a dose of 25 mg should be considered see sections 4. See section 4. Excipient with known effect: SmPC Patient Leaflet.